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Frontiers | The assessment of the potential hepatotoxicity of new drugs by in vitro metabolomics

25 However, the stage of development for these biomarkers and how they will be integrated into clinical strategy remain unclear

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The results demonstrated that these nanocarriers possess characteristics enabling them to access the brain, and they are at least as effective as the corresponding free drugs in protecting against rotenone-induced reduction in cell viability, increased iron content, and oxidative stress